Search results for "Precursor proliferationFGF-2"

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Nicotine-induced fibroblast growth factor-2 restores the age-related decline of precursor cell proliferation in the subventricular zone of rat brain.

2007

Precursor cell proliferation is present in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus of adult rat and persists during aging although at reduced levels. Previous studies have shown that acute intermittent nicotine treatment significantly increases fibroblast growth factor-2 (FGF-2) expression in several brain regions of aged rats. The aim of the present investigation was to test the hypothesis that nicotine-induced expression of FGF-2 may restore the age-related decline of precursor cell proliferation. It was first demonstrated that nicotine treatment increases both mRNA and protein FGF-2 in the SVZ of aged …

Malemedicine.medical_specialtyAgingNicotineBasic fibroblast growth factorSubventricular zoneCell CountNerve Tissue ProteinsBiologyFibroblast growth factorSettore BIO/09 - FisiologiaAntibodiesSubgranular zoneNestinchemistry.chemical_compoundIntermediate Filament ProteinsInternal medicinePrecursor cellLateral VentriclesGlial Fibrillary Acidic ProteinmedicineAnimalsNicotinic AgonistsRats WistarMolecular BiologyCell ProliferationAnalysis of VarianceCell growthGeneral NeuroscienceDentate gyrusFibroblast growth factor receptor 1BrainPrecursor proliferationFGF-2 FGFR1 SVZ Nicotine AgedRatsAdult Stem CellsEndocrinologymedicine.anatomical_structurenervous systemchemistryBromodeoxyuridineGene Expression RegulationFibroblast Growth Factor 2Neurology (clinical)Developmental BiologyBrain research
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